Speaker: Dr. Cydney Nielsen, British Columbia Cancer Agency
Title: "From Data to Insight: Computational Approaches and Future Challenges in Genomics"
High-throughput technologies are changing the scale and resolution at which we can investigate cellular states. We require improved computational methods to help us make sense of our growing data resources, but deriving new biological insight requires human judgment and cannot be achieved with automation alone. I will present my recent work in developing data analysis methods that exploit synergies between human visual reasoning and machine computation. These approaches tackle questions in genome sequencing, where reconstructing the genomic sequence from short sequencing fragments remains a challenge, and in epigenomics, where identifying cell type specific changes in DNA packaging and methylation promises to improve our understanding of both normal and diseased states. I will end by outlining some of the challenges ahead and discuss the applications of this work to cancer genomics and the analysis of complex interaction networks.
Cydney Nielsen obtained her BSc degree from the University of British Columbia in Microbiology and Immunology in 2001. After two years as a genomics data analyst at the Broad Institute in Cambridge, MA, she went on to complete a PhD in computational biology at MIT in 2008 under the supervision of Dr. Christopher Burge. She is currently a CIHR and MSFHR postdoctoral fellow at the British Columbia Cancer Agency, Genome Sciences Centre, working with Dr. Steven Jones. Her reseach focuses on developing methods for performing automated analyses and interactive data explorations, exploiting synergies between the two to answer pressing questions in genomics.
This is a joint talk with the Donnelly Centre for Cellular and BioMolecular Research and the Department of Comptuer Science
For additional Information, Contact: Mike Brudno