Speaker: Janusz Dutkowski
University of California, San Diego
Title: Turning networks into ontologies of gene function
Ontologies are of key importance to many domains of biological research. The Gene Ontology (GO), in particular, has proven instrumental in unifying knowledge about biological processes, cellular components, and molecular functions through a hierarchy of concepts and their interrelationships. However, given only partial biological knowledge and inconsistency in how this knowledge is curated, it has been difficult to construct, extend and validate GO in an unbiased manner. To address this problem we have recently developed a new computational system that infers ontological representations automatically from large-scale maps of gene and protein interactions. The result is a network-extracted ontology (NeXO), which contains 4,123 biological concepts and 5,766 hierarchical concept relations, capturing the majority of known cellular components and identifying approximately 600 new components and component relations. As we show, many new components can be validated using a combination of experimental, bioinformatic and curation approaches, and used directly to update the Gene Ontology structure. In my talk I will discuss how NeXO may serve as the basis for powerful new tools for molecular biology, enabling multiscale analysis of biological networks and providing evolvable models of the cell that are validated, revised, and expanded based on new genomic data. I will also discuss perspectives for using NeXO to build multiscale network models of human disease and other biological processes.
Joint talk with the Donnelly Centre for Cellular and BioMolecular Research and the Department of Computer Science
See event poster here.
For Additional Information, Contact: Quaid Morris